Placebo effect is stronger in people with psychological/neurological problems. So the SSRIs still work, it's just more difficult to prove by comparing against placebo.
That is indeed an interesting detail.
This still leaves open the issue of whether or not SSRIs should be prescribed if a sugar pill works just as well, on average.
I don't see that it can do any harm to try the placebo first in cases where the doctor believes it prudent. I'm pretty certain the major drug company reps would even agree, provided the patient buys the sugar pills from them at the same price as the actual drug.... :p
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I don't see that it can do any harm to try the placebo first in cases where the doctor believes it prudent. I'm pretty certain the major drug company reps would even agree, provided the patient buys the sugar pills from them at the same price as the actual drug.... :p